WO2024236538 - AZETIDINE LINKED BICYCLIC HETEROCYCLYL COMPOUNDS AS CCR4 MODULATORS
National phase entry is expected:
Publication Number
WO/2024/236538
Publication Date
21.11.2024
International Application No.
PCT/IB2024/054799
International Filing Date
17.05.2024
Title **
[English]
AZETIDINE LINKED BICYCLIC HETEROCYCLYL COMPOUNDS AS CCR4 MODULATORS
[French]
COMPOSÉS HÉTÉROCYCLYLE BICYCLIQUES LIÉS À L'AZÉTIDINE EN TANT QUE MODULATEURS DE CCR4
Applicants **
AURIGENE ONCOLOGY LIMITED
39/40(P), KIADB Industrial Area,
Electronics City Phase II, Bangalore,
Karnataka- 560 100, IN
Inventors
ABBINENI, Chandrasekhar
Plot#387, IKIGAI, Journalists’ colony phase 3, Gopanpally, Hyderabad,
Telangana 500032, IN
SAMAJDAR, Susanta
R801, HM Tambourine, JP Nagar 6th Phase, Bangalore, Karnataka 560078, IN
TALLURI, Krishna Chaitanya
Flat No. 401, Srinadha Nilayam, opp. ALIND Employees colony park, Sudarshan Nagar, Lingampally, Hyderabad, Telangana 500019, IN
MUKHERJEE, Subhendu
B208, SLV Sankalpa, Naganathapura, Central Jail Road, Bangalore,
Karnataka 560100, IN
MIDUTURU, Chandrasekhar V
134 Vassal Ln, Cambridge,
Cambridge, Massachusetts 02138, US
Priority Data
202341034417
17.05.2023
IN
Application details
| Total Number of Claims/PCT | * |
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| Sequence Listing | * |
| International Search Report is established | *
International Searching Authority
EPO
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| Applicant's Legal Status |
Legal Entity
* * * * * |
| Entry into National Phase under |
Chapter I
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| Translation |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing | 2264 | |
| EPO | Filing, Examination | 14828 | |
| Japan | Filing | 560 | |
| South Korea | Filing | 577 | |
| USA | Filing, Examination | 15435 |
Total: 33664 USD
Abstract[English]
The present disclosure provides azetidine linked bicyclic heterocyclyl compounds of formula (I-1), which are therapeutically useful as CCR4 modulators. These compounds are useful in the treatment and/or prevention of diseases and/or disorders responsive to the modulation of CCR4 activity. Compounds of the present disclosure are especially useful for treating cancer and inflammatory diseases and disorders. The present disclosure also provides processes for preparation of the compounds and pharmaceutical formulations comprising at least one of the compounds of formula (I-1) or a pharmaceutically acceptable salt or a stereoisomer thereof.[French]
La présente divulgation concerne des composés hétérocyclyle bicycliques liés à l'azétidine de formule (I-1), qui sont thérapeutiquement utiles en tant que modulateurs de CCR4. Ces composés sont utiles dans le traitement et/ou la prévention de maladies et/ou de troubles sensibles à la modulation de l'activité de CCR4. Les composés selon la présente divulgation sont particulièrement utiles pour le traitement du cancer et de maladies et de troubles inflammatoires. La présente divulgation concerne également des procédés de préparation des composés et des formulations pharmaceutiques comprenant au moins l'un des composés de formule (I-1) ou un sel ou un stéréoisomère pharmaceutiquement acceptable de ceux-ci.