WO2024244953 - A REACTION PROCESS AND BIOCATALYST FOR PREPARING ENANTIOPURE (S) -4-PHENYL-2-OXAZOLIDINONE

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Publication Number WO/2024/244953
Publication Date 05.12.2024
International Application No. PCT/CN2024/092820
International Filing Date 13.05.2024
Title [English] A REACTION PROCESS AND BIOCATALYST FOR PREPARING ENANTIOPURE (S) -4-PHENYL-2-OXAZOLIDINONE [French] PROCÉDÉ DE RÉACTION ET BIOCATALYSEUR POUR LA PRÉPARATION DE (S) -4-PHÉNYL-2-OXAZOLIDINONE ÉNANTIOPURE
Applicants ** ENZYMASTER (NINGBO) BIO-ENGINEERING CO., LTD. North Century Avenue, (6-21) - (6-27), Block 015 333 Ningbo, Zhejiang 315000, CN
Inventors ** YANG, Xinhang 333 North Century Avenue, (6-21) - (6-27), Block 015 Ningbo, Zhejiang 315000, CN ZHAO, Xin 333 North Century Avenue, (6-21) - (6-27), Block 015 Ningbo, Zhejiang 315000, CN LUO, Xiao 333 North Century Avenue, (6-21) - (6-27), Block 015 Ningbo, Zhejiang 315000, CN XIE, Hongmei 333 North Century Avenue, (6-21) - (6-27), Block 015 Ningbo, Zhejiang 315000, CN HONG, Zhongjie 333 North Century Avenue, (6-21) - (6-27), Block 015 Ningbo, Zhejiang 315000, CN DAI, Yixin 333 North Century Avenue, (6-21) - (6-27), Block 015 Ningbo, Zhejiang 315000, CN SUN, Fenshuai 333 North Century Avenue, (6-21) - (6-27), Block 015 Ningbo, Zhejiang 315000, CN ZHAO, Junxia North Century Avenue, (6-21) - (6-27), Block 015 333 Ningbo, Zhejiang 315000, CN HE, Kuifang (6-21) - (6-27), Block 015 333 North Century Avenue Ningbo, Zhejiang 315000, CN ZHAO, Jialun North Century Avenue, (6-21) - (6-27), Block 015 333 Ningbo, Zhejiang 315000, CN CHEN, Haibin (6-21) - (6-27), Block 015 333 North Century Avenue Ningbo, Zhejiang 315000, CN
Priority Data 202310640536.9  31.05.2023  CN
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Quotation for National Phase entry

Country Stages Total
China Filing 949
EPO Filing, Examination 6372
Japan Filing 572
South Korea Filing 578
USA Filing, Examination 4435
MasterCard Visa
Total: 12906
Abstract [English] Provided are improved engineered halohydrin dehalogenases that can tolerate high substrate concentrations and has high substrate specificity and activity. The engineered halohydrin dehalogenase is capable of converting (R) -styrene oxide from racemic styrene oxide to (S) -4-phenyl-2-oxazolidinone; and resolving racemic styrene oxide to obtain (S)-styrene oxide in high purity. [French] La présente invention concerne des halohydrines déhalogénases améliorées qui peuvent tolérer des concentrations élevées de substrat et qui présentent une spécificité et une activité de substrat élevées. L'halohydrine déhalogénase modifiée peut convertir l'oxyde de styrène (R) de l'oxyde de styrène racémique en (S) -4-phényl-2-oxazolidinone ; et résoudre l'oxyde de styrène racémique pour obtenir de l'oxyde de (S)-styrène d'une grande pureté.