WO2023187697 - PROCESS FOR THE PREPARATION OF BELUMOSUDIL MESYLATE AND ITS CRYSTALLINE FORM

National phase entry:
Publication Number WO/2023/187697
Publication Date 05.10.2023
International Application No. PCT/IB2023/053174
International Filing Date 30.03.2023
Title [English] PROCESS FOR THE PREPARATION OF BELUMOSUDIL MESYLATE AND ITS CRYSTALLINE FORM [French] PROCÉDÉ DE PRÉPARATION DE MÉSYLATE DE BELUMOSUDIL ET SA FORME CRISTALLINE
Applicants ** GLENMARK LIFE SCIENCES LIMITED Plot No. 170-172, Chandramouli Industrial Estate, Mohol Bazarpeth Solapur 413213, IN
Inventors ** PALLE, Venkata Raghavendra Acharyulu Bungalow 24, Gera Green Ville, Survey no. 64 Grant Road, Kharadi, Maharashtra, 411014 Pune, India Pune 411014, IN PATEL, Pratik 7, Anand Vihar, Gotri Vasna Road, Gotri, Vadodara Gujarat, India, 390021 Vadodara 390021, IN KUMAR, Gaurav A-1103, Europa CHS LTD, Casa Bella Gold, Kalyan Shil Road, Nilje Gaon, Thane, Maharashtra, India, 421204 Thane 421204, IN RAMAR, Subbiah I-304, Earth Artica, Vasna-Bhayali Link Road, Vadodara, Gujarat, India, 390007 Vadodara 390007, IN DATTA, Swarup AT + P.O.-Khatra, Khatra Hospital Road, Khatra, Bankura, West Bengal, India, 722140 Bankura 722140, IN JAGDHANE, Rajendra A-502, Sudarshan Paradise Hsg Soc, Vishal nagar, pimple nilakh, Pune, Maharashtra, India, 411027 Pune 411027, IN GUNJAL, Navnath 138, Magar Vasti, A/P-Sadatapur, Tal-Sangamner Ahmednagar, India, 413736 Ahmednagar 413736, IN CHAPALA, Kotaiah 13-65/1, Ramalaya street, gonepudi, Narasaraopeta, guntur, Andhra Pradesh, India, 522601 Guntur 522601, IN
Priority Data 202221019468  31.03.2022  IN 202221031471  01.06.2022  IN 202221035548  21.06.2022  IN 202221050263  02.09.2022  IN 202221059116  17.10.2022  IN
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Abstract [English] The present invention relates to a process for the preparation of belumosudil mesylate and its crystalline form. Further, the present invention relates to a 10 pharmaceutical composition comprising a therapeutically effective amount of the crystalline form of belumosudil mesylate obtained by the process of the present invention. [French] La présente invention concerne un procédé de préparation de mésylate de belumosudil et sa forme cristalline. En outre, la présente invention concerne une composition pharmaceutique comprenant une quantité thérapeutiquement efficace de la forme cristalline du mésylate de belumosudil obtenue par le procédé de la présente invention.