WO2023227997 - PHARMACEUTICAL COMPOSITION CONTAINING COMBINATION OF AZILSARTAN AND CHLORTHALIDONE AND PROCESS OF PREPARATION THEREOF

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Publication Number WO/2023/227997
Publication Date 30.11.2023
International Application No. PCT/IB2023/054928
International Filing Date 12.05.2023
Title [English] PHARMACEUTICAL COMPOSITION CONTAINING COMBINATION OF AZILSARTAN AND CHLORTHALIDONE AND PROCESS OF PREPARATION THEREOF [French] COMPOSITION PHARMACEUTIQUE CONTENANT UNE COMBINAISON D'AZILSARTAN ET DE CHLORTHALIDONE ET SON PROCÉDÉ DE PRÉPARATION
Applicants ** ALEMBIC PHARMACEUTICALS LIMITED Alembic Research Centre, Alembic road, Vadodara Vadodara 390003, IN
Inventors ** REDDY, Konda Ramakrishna Alembic Pharmaceuticals Limited, Lab Suites 111-112 & 113-114 on Ground Floor Lab Suites 123 & 124 on First Floor Block –1, Building 450 MN Park, Genome Valley, Shameerpet Turkapally (V) Medchal District Hyderabad Hyderabad 500078, IN SAHOO, Ashok kumar Alembic Pharmaceuticals Limited, Lab Suites 111-112 & 113-114 on Ground Floor Lab Suites 123 & 124 on First Floor Block –1, Building 450 MN Park, Genome Valley, Shameerpet Turkapally (V) Medchal District Hyderabad Hyderabad 500078, IN SAHOO, Barada Prasanna Alembic Pharmaceuticals Limited, Lab Suites 111-112 & 113-114 on Ground Floor Lab Suites 123 & 124 on First Floor Block –1, Building 450 MN Park, Genome Valley, Shameerpet Turkapally (V) Medchal District Hyderabad Hyderabad 500078, IN DABRE, Dr Rahul Sudhakar Alembic Pharmaceuticals Limited, Lab Suites 111-112 & 113-114 on Ground Floor Lab Suites 123 & 124 on First Floor Block –1, Building 450 MN Park, Genome Valley, Shameerpet Turkapally (V) Medchal District Hyderabad Hyderabad 500078, IN
Priority Data 202221029541  23.05.2022  IN
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Abstract [English] The present subject matter relates to a solid oral pharmaceutical composition comprising combination of azilsartan and chlorthalidone or a pharmaceutically acceptable salt thereof with at least one pharmaceutically acceptable excipient. The present subject matter also relates to a fixed dose pharmaceutical composition comprising azilsartan and chlorthalidone or a pharmaceutically acceptable salt thereof with at least one pharmaceutically acceptable excipient. Furthermore, it also relates to methods for manufacturing such compositions and use thereof. [French] La présente invention concerne une composition pharmaceutique orale solide comprenant une combinaison d'azilsartan et de chlorthalidone ou d'un sel pharmaceutiquement acceptable de ceux-ci avec au moins un excipient pharmaceutiquement acceptable. La présente invention concerne également une composition pharmaceutique à dose fixe comprenant de l'azilsartan et de la chlorthalidone ou un sel pharmaceutiquement acceptable de ceux-ci avec au moins un excipient pharmaceutiquement acceptable. En outre, l'invention concerne également des procédés de fabrication de telles compositions et leur utilisation.