WO2023238078 - )-ENGINEERED OXYNITRILASE POLYPEPTIDES AND USES THEREOF

National phase entry:
Publication Number WO/2023/238078
Publication Date 14.12.2023
International Application No. PCT/IB2023/055923
International Filing Date 08.06.2023
Title [English] )-ENGINEERED OXYNITRILASE POLYPEPTIDES AND USES THEREOF [French] ) ET LEURS UTILISATIONS
Applicants ** NOVARTIS AG Lichtstrasse 35 4056 Basel, CH
Inventors ** ALVIZO, Oscar 200 Penobscot Drive Redwood City, California 94063, US LUESCHER, Michael Umberto Novartis Pharma AG Postfach 4002 Basel, CH MANN, Gregory Novartis Pharma AG Postfach 4002 Basel, CH MARTIN, Benjamin Novartis Pharma AG Postfach 4002 Basel, CH NOVICK, Scott J. 200 Penobscot Drive Redwood City, California 94063, US Ó MEADHRA, Ruairí Seosamh Novartis Pharma AG Postfach 4002 Basel, CH PESCHKE, Theo Novartis Pharma AG Postfach 4002 Basel, CH SCHLAMA, Thierry Novartis Pharma AG Postfach 4002 Basel, CH SCHOBER, Lukas Christian Novartis Pharma AG Postfach 4002 Basel, CH SCHROER, Kirsten Novartis Pharma AG Postfach 4002 Basel, CH STANGER, Frederic Novartis Pharma AG Postfach 4002 Basel, CH SUBRAMANIAN, Nandhitha 7 James Nurse Close Cambridge CB1 9LJ, GB TRUNG, Nhat Quang Nguyen Novartis Pharma AG Postfach 4002 Basel, CH
Priority Data 63/350,047  08.06.2022  US
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Quotation for National Phase entry

Country Stages Total
China Filing 2943
EPO Filing, Examination 29850
Japan Filing 573
South Korea Filing 578
USA Filing, Examination 16485
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Abstract [English] The present disclosure relates to a process for producing chiral β-nitro alcohol compounds. The invention relates in particular to an (S)-selective oxynitrilase, which enantioselectively can catalyze the Henry reaction, wherein an aldehyde or ketone compound is converted to the corresponding β-nitro alcohol compound in the presence of a nitroalkane compound and an oxynitrilase. [French] La présente divulgation concerne un procédé de production de composés de β-nitro-alcools chiraux. La présente divulgation concerne plus particulièrement une oxynitrilase (S)-sélective, qui peut catalyser de manière énantiosélective la réaction de Henry, dans laquelle un composé aldéhyde ou cétone est converti en composé β-nitro-alcool correspondant en présence d'un composé nitro-alcane et d'une oxynitrilase.