WO2024003749 - COMPOUNDS AND METHODS FOR DEGRADING CASEIN KINASE 1 ALPHA

National phase entry:
Publication Number WO/2024/003749
Publication Date 04.01.2024
International Application No. PCT/IB2023/056639
International Filing Date 27.06.2023
Title [English] COMPOUNDS AND METHODS FOR DEGRADING CASEIN KINASE 1 ALPHA [French] COMPOSÉS ET PROCÉDÉS DE DÉGRADATION DE LA CASÉINE KINASE 1 ALPHA
Applicants ** PIN THERAPEUTICS, INC. 46, Wiryeseoil-ro, Sujeong-gu Seongnam-si Gyeonggi-do 13646, KR
Inventors ** JO, Hyunsun 4th Floor, 46, Wiryeseoil-ro, Sujeong-gu Seongnam-si Gyeonggi-do 13646, KR TERRETT, Nicholas Kenneth 60 Hamp Road Lambertville, New Jersey 08530, US LEVY, Daniel Emil 37 Lakewood Circle San Mateo, California 94402, US DENINNO, Michael Paul 9 Hermitage Dr Gales Ferry, Connecticut 06335, US KING-UNDERWOOD, John Moorend Cottage Pendock GL19 3PW, GB CHUNG, Jun-Jae 329 Oyster Point Blvd, Suite 3403 South San Francisco, California 94080, US MOHANTY, Sarina 250 S El Molino Ave #18 Pasadena, California 91101, US PARK, Jisu 4th Floor, 46, Wiryeseoil-ro, Sujeong-gu Seongnam-si Gyeonggi-do 13646, KR KIM, Purum 4th Floor, 46, Wiryeseoil-ro, Sujeong-gu Seongnam-si Gyeonggi-do 13646, KR PARK, Yuna 4th Floor, 46, Wiryeseoil-ro, Sujeong-gu Seongnam-si Gyeonggi-do 13646, KR JAIPURI, Firoz Ali 37330 Portico Ter Fremont, California 94536, US
Priority Data 63/355,840  27.06.2022  US 63/447,528  22.02.2023  US 63/471,723  07.06.2023  US
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China Filing 10427
EPO Filing, Examination 31720
Japan Filing 574
South Korea Filing 645
USA Filing, Examination 17035
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Abstract [English] Provided are novel compounds represented by Formula (I) which degrade CK1α (casein kinase 1 alpha), and methods of degrading CK1α, or preventing or treating blood cancer by administering the compounds to a subject in need thereof. [French] L'invention concerne de nouveaux composés représentés par la formule (I) qui dégradent la CK1α (caséine kinase 1 alpha), et des procédés de dégradation de la CK1α, ou de prévention ou de traitement du cancer du sang par administration des composés à un sujet en ayant besoin.