WO2024038378 - SUBSTITUTED PYRIDINONE COMPOUNDS AS CBL-B INHIBITORS

National phase entry:
Publication Number WO/2024/038378
Publication Date 22.02.2024
International Application No. PCT/IB2023/058197
International Filing Date 15.08.2023
Title [English] SUBSTITUTED PYRIDINONE COMPOUNDS AS CBL-B INHIBITORS [French] COMPOSÉS DE PYRIDINONE SUBSTITUÉS UTILISÉS EN TANT QU'INHIBITEURS DE CBL-B
Applicants ** GLENMARK PHARMACEUTICALS LTD B/2, Mahalaxmi Chambers, 22 Bhulabhai Desai Road, Maharashtra Mumbai - 400026, IN
Inventors ** CHINNAPATTU, Murugan Glenmark Research Centre, Plot No. A-607, T.T.C. Industrial Area, M.I.D.C., Mahape, Maharashtra Navi Mumbai 400709, IN CHAUDHARI, Sachin Glenmark Research Centre, Plot No. A-607, T.T.C. Industrial Area, M.I.D.C., Mahape, Maharashtra Navi Mumbai 400709, IN GOWDA, Nagaraj Glenmark Research Centre, Plot No. A-607, T.T.C. Industrial Area, M.I.D.C., Mahape, Maharashtra Navi Mumbai 400709, IN DAS, Sanjib Glenmark Research Centre, Plot No. A-607, T.T.C. Industrial Area, M.I.D.C., Mahape, Maharashtra Navi Mumbai 400709, IN IYER, Pravin Glenmark Research Centre, Plot No. A-607, T.T.C. Industrial Area, M.I.D.C., Mahape, Maharashtra Navi Mumbai 400709, IN WAGHMARE, Nayan Glenmark Research Centre, Plot No. A-607, T.T.C. Industrial Area, M.I.D.C., Mahape, Maharashtra Navi Mumbai 400709, IN SHELKE, Sandeep Glenmark Research Centre, Plot No. A-607, T.T.C. Industrial Area, M.I.D.C., Mahape, Maharashtra Navi Mumbai 400709, IN GAVHANE, Balasaheb Glenmark Research Centre, Plot No. A-607, T.T.C. Industrial Area, M.I.D.C., Mahape, Maharashtra Navi Mumbai 400709, IN SAINI, Jagmohan Glenmark Research Centre, Plot No. A-607, T.T.C. Industrial Area, M.I.D.C., Mahape, Maharashtra Navi Mumbai 400709, IN KADAM, Sheetal Glenmark Research Centre, Plot No. A-607, T.T.C. Industrial Area, M.I.D.C., Mahape, Maharashtra Navi Mumbai 400709, IN
Priority Data 202221046493  16.08.2022  IN
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Quotation for National Phase entry

Country Stages Total
China Filing 4682
EPO Filing, Examination 58827
Japan Filing 568
South Korea Filing 578
USA Filing, Examination 62785
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Total: 127440
The term for entry into the National Phase has expired. This quotation is for informational purposes only.

Abstract [English] The present invention is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, which are useful as CBL-b inhibitors, processes for their preparation, pharmaceutical compositions comprising the compounds, and the use of the compounds or the compositions in the treatment or prevention of various diseases, conditions and/or disorders mediated by CBL-b. [French] La présente invention concerne des composés de formule (I) et des sels pharmaceutiquement acceptables de ceux-ci, qui sont utiles en tant qu'inhibiteurs de CBL-b, des procédés pour leur préparation, des compositions pharmaceutiques comprenant les composés, et l'utilisation des composés ou des compositions dans le traitement ou la prévention de maladies, d'affections et/ou de troubles divers à médiation par CBL-b