Publication Number
WO/2024/121632
Publication Date
13.06.2024
International Application No.
PCT/IB2023/059716
International Filing Date
28.09.2023
Title
[English]
USE OF ANTI-CD117 ANTIBODY DRUG CONJUGATE (ADC)
[French]
UTILISATION D'UN CONJUGUÉ ANTICORPS-MÉDICAMENT (ADC) ANTI-CD117
Applicants **
CRISPR THERAPEUTICS AG
BAARERSTRASSE 14
6300 ZUG, CH
Inventors **
BERTELSEN, Kirk
100 Technology Square, 5th Floor
Cambridge, Massachusetts 02139, US
Priority Data
63/386,891
09.12.2022
US
63/386,919
11.12.2022
US
63/479,535
11.01.2023
US
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Abstract
[English]
The invention relates to uses of an anti-CD117 antibody drug conjugate (ADC) comprising an anti-CD117 antibody conjugated to an amatoxin via a linker, for targeted conditioning a human patient in need thereof for hematopoietic stem cell (HSC) transplantation. Also provided is a method for depleting CD117+ cells, e.g., endogenous HSCs, in a human patient in need thereof.
[French]
L'invention concerne des utilisations d'un conjugué anticorps-médicament (ADC) anti-CD117 comprenant un anticorps anti-CD117 conjugué à une amatoxine par l'intermédiaire d'un lieur, pour le conditionnement ciblé d'un patient humain en ayant besoin pour une transplantation de cellules souches hématopoïétiques (HSC). L'invention concerne également une méthode de déplétion de cellules CD117+, par exemple, des HSC endogènes, chez un patient humain en ayant besoin.