Publication Number
WO/2025/037249
Publication Date
20.02.2025
International Application No.
PCT/IB2024/057866
International Filing Date
13.08.2024
Title
[English]
FAP TARGETING CYCLIC PEPTIDES AND CONJUGATES THEREOF
[French]
PEPTIDES CYCLIQUES CIBLANT LA FAP ET CONJUGUÉS ASSOCIÉS
Applicants **
NOVARTIS AG
Lichtstrasse 35
4056 Basel, CH
Inventors **
BONGARZONE, Salvatore
ADVANCED ACCELERATOR APPLICATIONS (ITALY) - S.R.L.
Via dell'industria Prima Traversa
86077 Pozzilli (ISERNIA), IT
CAMPORESE, Davide
ADVANCED ACCELERATOR APPLICATIONS (ITALY) - S.R.L.
Via dell'industria Prima Traversa
86077 Pozzilli (ISERNIA), IT
CLEMENTE, Gonçalo dos Santos
Novartis Pharma AG
Lichtstrasse 35
4056 Basel, CH
EHARA, Takeru
PEPTIDREAM INC. (also known as PEPTIDREAM K.K.)
3-25-23, Tonomachi, Kawasaki-ku, Kawasaki-shi
Kanagawa, 210-0821, JP
FISCHER, Matteo
Novartis Pharma AG
Lichtstrasse 35
4056 Basel, CH
GOLOSOV, Andrei Alexandrovich
Novartis Institutes for BioMedical Research, Inc.
250 Massachusetts Avenue
Cambridge, Massachusetts 02139, US
GROSCHE, Philipp
Novartis Pharma AG
Lichtstrasse 35
4056 Basel, CH
HOLZER, Philipp
Novartis Pharma AG
Lichtstrasse 35
4056 Basel, CH
KARPOV, Alexei
Novartis Pharma AG
Lichtstrasse 35
4056 Basel, CH
LACAUD-BAUMLIN, Marion
Novartis Pharma AG
Lichtstrasse 35
4056 Basel, CH
LEDER, Lukas
Novartis Pharma AG
Lichtstrasse 35
4056 Basel, CH
MALO, Rafael Bermeo
Novartis Pharma AG
Lichtstrasse 35
4056 Basel, CH
MARZINZIK, Andreas
Novartis Pharma AG
Lichtstrasse 35
4056 Basel, CH
MIZUKOSHI, Yoshihide
PEPTIDREAM INC. (also known as PEPTIDREAM K.K.)
3-25-23, Tonomachi, Kawasaki-ku, Kawasaki-shi
Kanagawa, 210-0821, JP
MUNSCH, Charlie
Novartis Pharma AG
Lichtstrasse 35
4056 Basel, CH
RESCHKE, Markus Oliver
Novartis Pharma AG
Lichtstrasse 35
4056 Basel, CH
SELLNER, Holger
Novartis Pharma AG
Lichtstrasse 35
4056 Basel, CH
STACHYRA, Therese-Marie
Novartis Pharma AG
Lichtstrasse 35
4056 Basel, CH
Priority Data
63/519,599
 15.08.2023
 US
63/650,139
 21.05.2024
 US
Application details
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Abstract
[English]
Described herein are cyclic peptides targeting fibroblast activation protein (FAP), and their incorporation into compounds for radioligand imaging and therapies, as well as methods and/or uses of such compounds for the imaging, treatment and/or prevention of FAP-implicated diseases and disorders.
[French]
L'invention concerne des peptides cycliques ciblant la protéine d'activation des fibroblastes (FAP), et leur incorporation dans des composés pour l'imagerie et les thérapies par radioligands, ainsi que des méthodes et/ou des utilisations de tels composés pour l'imagerie, le traitement et/ou la prévention de maladies et de troubles associés à la FAP.