WO2025037249 - FAP TARGETING CYCLIC PEPTIDES AND CONJUGATES THEREOF

National phase entry is expected:
Publication Number WO/2025/037249
Publication Date 20.02.2025
International Application No. PCT/IB2024/057866
International Filing Date 13.08.2024
Title [English] FAP TARGETING CYCLIC PEPTIDES AND CONJUGATES THEREOF [French] PEPTIDES CYCLIQUES CIBLANT LA FAP ET CONJUGUÉS ASSOCIÉS
Applicants ** NOVARTIS AG Lichtstrasse 35 4056 Basel, CH
Inventors ** BONGARZONE, Salvatore ADVANCED ACCELERATOR APPLICATIONS (ITALY) - S.R.L. Via dell'industria Prima Traversa 86077 Pozzilli (ISERNIA), IT CAMPORESE, Davide ADVANCED ACCELERATOR APPLICATIONS (ITALY) - S.R.L. Via dell'industria Prima Traversa 86077 Pozzilli (ISERNIA), IT CLEMENTE, Gonçalo dos Santos Novartis Pharma AG Lichtstrasse 35 4056 Basel, CH EHARA, Takeru PEPTIDREAM INC. (also known as PEPTIDREAM K.K.) 3-25-23, Tonomachi, Kawasaki-ku, Kawasaki-shi Kanagawa, 210-0821, JP FISCHER, Matteo Novartis Pharma AG Lichtstrasse 35 4056 Basel, CH GOLOSOV, Andrei Alexandrovich Novartis Institutes for BioMedical Research, Inc. 250 Massachusetts Avenue Cambridge, Massachusetts 02139, US GROSCHE, Philipp Novartis Pharma AG Lichtstrasse 35 4056 Basel, CH HOLZER, Philipp Novartis Pharma AG Lichtstrasse 35 4056 Basel, CH KARPOV, Alexei Novartis Pharma AG Lichtstrasse 35 4056 Basel, CH LACAUD-BAUMLIN, Marion Novartis Pharma AG Lichtstrasse 35 4056 Basel, CH LEDER, Lukas Novartis Pharma AG Lichtstrasse 35 4056 Basel, CH MALO, Rafael Bermeo Novartis Pharma AG Lichtstrasse 35 4056 Basel, CH MARZINZIK, Andreas Novartis Pharma AG Lichtstrasse 35 4056 Basel, CH MIZUKOSHI, Yoshihide PEPTIDREAM INC. (also known as PEPTIDREAM K.K.) 3-25-23, Tonomachi, Kawasaki-ku, Kawasaki-shi Kanagawa, 210-0821, JP MUNSCH, Charlie Novartis Pharma AG Lichtstrasse 35 4056 Basel, CH RESCHKE, Markus Oliver Novartis Pharma AG Lichtstrasse 35 4056 Basel, CH SELLNER, Holger Novartis Pharma AG Lichtstrasse 35 4056 Basel, CH STACHYRA, Therese-Marie Novartis Pharma AG Lichtstrasse 35 4056 Basel, CH
Priority Data 63/519,599  15.08.2023  US 63/650,139  21.05.2024  US
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Quotation for National Phase entry

Country Stages Total
China Filing 6497
EPO Filing, Examination 60172
Japan Filing 564
South Korea Filing 612
USA Filing, Examination 26735
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Abstract [English] Described herein are cyclic peptides targeting fibroblast activation protein (FAP), and their incorporation into compounds for radioligand imaging and therapies, as well as methods and/or uses of such compounds for the imaging, treatment and/or prevention of FAP-implicated diseases and disorders. [French] L'invention concerne des peptides cycliques ciblant la protéine d'activation des fibroblastes (FAP), et leur incorporation dans des composés pour l'imagerie et les thérapies par radioligands, ainsi que des méthodes et/ou des utilisations de tels composés pour l'imagerie, le traitement et/ou la prévention de maladies et de troubles associés à la FAP.